After several decades of research, this diagnosis was refined and improved several times. The 3rd edition of the DSM introduced the diagnosis of PTSD with 17 symptoms divided into three clusters in 1980. Both the manifestation and etiology of it are complex, which has caused difficulty in defining and diagnosing the condition. Posttraumatic stress disorder is a prevalent and typically debilitating psychiatric syndrome with a significant functional disturbance in various domains. The ones cited here are those that, in the authors’ view, make a substantial contribution to the interdisciplinary understanding of PTSD. This article is a selective review of pertinent literature retrieved by a search in PubMed, using the following keywords: “PTSD AND military personnel”. The aim of this review article is to present the current understanding of PTSD related to military injury to foster interdisciplinary dialog. Considering the significant medical, social and financial problems, PTSD represents both to nations and to individuals, all persons caring for patients suffering from this disease or under traumatic exposure should know about the risks of PTSD. However, both the underlying mechanism and specific treatment for the disease remain unclear. This disease first raised public concerns during and after the military operations of the United States in Afghanistan and Iraq, and to date, a large number of research studies report progress in this field. PTSD is a potentially chronic impairing disorder that is characterized by re-experience and avoidance symptoms as well as negative alternations in cognition and arousal. The diagnosis of PTSD was first introduced in the 3rd edition of the Diagnostic and Statistical Manual (DSM) (American Psychiatric Association) in 1980. Posttraumatic stress disorder (PTSD) is a recognized clinical phenomenon that often occurs as a result of exposure to severe stressors, such as combat, natural disaster, or other events. Future investigations are needed to determine which guideline or inspection method is the best for early diagnosis and which strategies might prevent the development of PTSD. Overall, the findings of pertinent studies are difficult to generalize because of heterogeneous patient groups, different traumatic events, diagnostic criteria, and study designs. Prevention and treatment methods for PTSD vary from psychological interventions to pharmacological medications. The morphological alternation of subcortical brain structures may also correlate with PTSD symptoms. Its pathogenesis is multifactorial, including the activation of the hypothalamic–pituitary–adrenal (HPA) axis, immune response, or even genetic discrepancy. Generally, PTSD is diagnosed according to several clusters of symptoms occurring after exposure to extreme stressors. There are several diagnostic guidelines for PTSD, with the most recent editions of the DSM-5 and ICD-11 being best accepted. This study is a selective review of literature aiming to provide a general outlook of the current understanding of PTSD. This disorder can result in a disturbance to individual and family functioning, causing significant medical, financial, and social problems. Posttraumatic stress disorder (PTSD) is a chronic impairment disorder that occurs after exposure to traumatic events.
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